The Spasmogenic and Spasmolytic Activities of Lavandula stoechas are Mediated Through Muscarinic Receptor Stimulation and Calcium Channel Blockade
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چکیده
منابع مشابه
The antidiarrheal and spasmolytic activities of Phyllanthus emblica are mediated through dual blockade of muscarinic receptors and Ca2+ channels.
AIM OF THE STUDY This study was aimed at providing the possible mechanisms for the medicinal use of Phyllanthus emblica in diarrhea. MATERIALS AND METHODS The in vivo studies were conducted in mice, while isolated rabbit jejunum and guinea-pig ileum were used for the in vitro experiments. RESULTS The crude extract of Phyllanthus emblica (Pe.Cr), which tested positive for alkaloids, tannins,...
متن کاملAntispasmodic and Antidiarrheal Activities of Valeriana hardwickii Wall. Rhizome Are Putatively Mediated through Calcium Channel Blockade
Valeriana hardwickii is indigenous to Pakistan, Burma and Ceylon, where it is traditionally being used as an antispasmodic and antidiarrheal, besides its culinary use as spice. The aim of this paper was to provide pharmacological validation to these medicinal uses. The crude aqueous-methanolic extract of Valeriana hardwickii rhizome (Vh.Cr) was studied on isolated rabbit jejunum and castor oil-...
متن کاملAntispasmodic and bronchodilator activities of Artemisia vulgaris are mediated through dual blockade of muscarinic receptors and calcium influx.
AIM OF THE STUDY The present study describes antispasmodic, antidiarrheal, bronchodilatory and tracheo-relaxant activities of Artemisia vulgaris to rationalize some of its traditional uses. MATERIALS AND METHODS Crude extract of Artemisia vulgaris (Av.Cr) was studied in the isolated tissue preparations of rabbit jejunum and guinea-pig trachea, as well as in the in vivo castor oil-induced diar...
متن کاملPresence of cholinomimetic and calcium channel blocking constituents in Carthamus oxycantha
The crude extract of Carthamus oxycantha (Co.Cr) was studied in vitro for its possible spasmogenic and spasmolytic activities. Segments of isolated rabbit jejunum 2-3 cm long were mounted in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide. Isotonic responses were measured on Bioscience oscillograph. Isotonic responses were measured on Bioscience oscillograph. Co.Cr caused dose-d...
متن کاملPresence of cholinomimetic and calcium channel blocking constituents in Carthamus oxycantha
The crude extract of Carthamus oxycantha (Co.Cr) was studied in vitro for its possible spasmogenic and spasmolytic activities. Segments of isolated rabbit jejunum 2-3 cm long were mounted in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide. Isotonic responses were measured on Bioscience oscillograph. Isotonic responses were measured on Bioscience oscillograph. Co.Cr caused dose-d...
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ژورنال
عنوان ژورنال: International Journal of Pharmacology
سال: 2006
ISSN: 1811-7775
DOI: 10.3923/ijp.2007.61.67